Gennaro Schettini Selected Research

Chemokine CXCL12

8/2008	Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas.
1/2007	CXCR4 and SDF1 expression in human meningiomas: a proliferative role in tumoral meningothelial cells in vitro.
12/2006	CXC receptor and chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation.
2/2006	Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals.
8/2005	Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation.
12/2004	CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line.
4/2003	Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt.
11/2002	Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro.

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Gennaro Schettini Research Topics

Disease

13	Neoplasms (Cancer) 01/2007 - 07/2002
9	Alzheimer Disease (Alzheimer's Disease) 05/2007 - 09/2002
6	Neuroblastoma 01/2007 - 02/2002
5	Glioblastoma (Glioblastoma Multiforme) 01/2007 - 11/2002
4	Pituitary Neoplasms (Pituitary Adenoma) 08/2008 - 10/2002
3	Meningioma (Meningiomas) 01/2007 - 01/2004
3	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2006 - 02/2002
3	Glioma (Gliomas) 10/2006 - 07/2004
2	Amyloid Plaque 10/2010 - 01/2007
2	Growth Hormone-Secreting Pituitary Adenoma 08/2008 - 07/2003
2	Ovarian Neoplasms (Ovarian Cancer) 08/2005 - 12/2004
2	Down Syndrome (Down's Syndrome) 12/2004 - 09/2002
2	Adenoma (Adenomas) 07/2003 - 10/2002
2	Brain Neoplasms (Brain Tumor) 11/2002 - 11/2002
1	Encephalitis (Encephalitis, Rasmussen) 01/2007
1	Brain Diseases (Brain Disorder) 01/2007
1	Meningeal Neoplasms 12/2006
1	Female Genital Diseases 08/2005
1	Neoplasm Metastasis (Metastasis) 08/2005
1	Carcinoma (Carcinomatosis) 01/2004
1	Ovarian Epithelial Carcinoma 01/2004
1	Sarcoma (Soft Tissue Sarcoma) 05/2003
1	Gliosis 04/2003
1	Niemann-Pick Diseases (Niemann Pick Disease) 02/2003
1	Necrosis 11/2002
1	Infections 11/2002
1	Pathologic Processes 11/2002
1	Acquired Immunodeficiency Syndrome (AIDS) 09/2002
1	Dementia (Dementias) 09/2002
1	Melanoma (Melanoma, Malignant) 07/2002
1	Lewis Lung Carcinoma 07/2002

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 05/2007 - 09/2002
9	Amyloid (Amyloid Fibrils)IBA 10/2010 - 09/2002
8	Amyloid beta-PeptidesIBA 10/2010 - 09/2002
8	ChemokinesIBA 08/2008 - 09/2002
8	Messenger RNA (mRNA)IBA 08/2008 - 04/2003
8	Chemokine CXCL12IBA 08/2008 - 11/2002
7	Peptides (Polypeptides)IBA 01/2007 - 09/2002
6	LigandsIBA 03/2007 - 11/2002
5	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 08/2008 - 07/2003
5	DNA (Deoxyribonucleic Acid)IBA 08/2008 - 07/2003
4	CXCR4 Receptors (CXCR4 Receptor)IBA 08/2008 - 11/2002
4	Growth Hormone (Somatotropin)IBA 08/2008 - 10/2002
4	Chemokine ReceptorsIBA 03/2007 - 11/2002
4	Prion ProteinsIBA 01/2007 - 02/2002
4	ThymidineIBA 01/2007 - 07/2003
4	Tyrosine (L-Tyrosine)FDA Link 04/2005 - 09/2002
4	Somatostatin Receptors (Somatostatin Receptor)IBA 07/2004 - 05/2003
3	Protein Isoforms (Isoforms)IBA 01/2007 - 10/2002
3	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2007 - 10/2002
2	Peptide Hydrolases (Proteases)FDA Link 01/2007 - 02/2002
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2007 - 12/2006
2	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 01/2007 - 12/2006
2	CXC ChemokinesIBA 10/2006 - 11/2002
2	ErbB Receptors (EGF Receptor)IBA 08/2005 - 12/2004
2	Bovine Serum AlbuminIBA 07/2003 - 04/2003
2	IST-FS 29IBA 11/2002 - 07/2002
2	triethyltinIBA 11/2002 - 07/2002
1	plerixafor FDA Link 08/2008
1	PresenilinsIBA 05/2007
1	ProlactinIBA 03/2007
1	Cholinergic Agents (Cholinergics)IBA 01/2007
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2007
1	Mitogen-Activated Protein Kinase 3IBA 01/2007
1	ParaffinIBA 01/2007
1	PrPSc ProteinsIBA 01/2007
1	Mucin-1 (CA 15-3 Antigen)IBA 01/2007
1	PrionsIBA 01/2007
1	Interleukin-8 (Interleukin 8)IBA 12/2006
1	Interferon-gamma (Interferon, gamma)IBA 12/2006
1	CXCR ReceptorsIBA 10/2006
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2004
1	phosphotyrosine phosphatase etaIBA 12/2004
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 09/2004
1	Protein Tyrosine PhosphatasesIBA 07/2004
1	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA 07/2004
1	Cyclin D1IBA 01/2004
1	Tetradecanoylphorbol AcetateIBA 01/2004
1	CarcinogensIBA 01/2004
1	Phorbol EstersIBA 07/2003
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 07/2003
1	Calcium Channels (Calcium Channel)IBA 07/2003
1	Hormones (Hormone)IBA 07/2003
1	lanreotide (Somatuline)FDA Link 07/2003
1	somatostatin receptor type 1IBA 07/2003
1	ColforsinIBA 07/2003
1	Vanadates (Orthovanadate)IBA 07/2003
1	Insulin-Like Growth Factor I (IGF-1)IBA 07/2003
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 07/2003
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 04/2003
1	Phosphotransferases (Kinase)IBA 04/2003
1	LipopolysaccharidesIBA 04/2003
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2003
1	prion protein (106-126)IBA 04/2003
1	EnzymesIBA 02/2003
1	TinIBA 11/2002
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2002
1	Leptin ReceptorsIBA 10/2002
1	LeptinIBA 10/2002

Therapy/Procedure

3	Therapeutics 01/2007 - 01/2004